Pharmacogenetics

Pharmacogenetics is the study of how people’s genotype affects their response to drugs.More and more, the prescription of active molecules is done after a molecular profile susceptibility study concerning the drug, in order to adapt the dosage and optimize the efficacy of the treatment, and also limiting the undesirable effects.The main genes implicated are the Cytochrome P450 gene family. Depending on the genetic profile, it is also possible to verify the therapeutic effect or the inefficacity of a molecule:

  • Genetic screening in order to determine the eligibility of patients to certain treatments
  • Genetic screening in order to detect an iatrogenic risk
  • Genetic screening of patients in order to define a better dosage
  • Genetic screening in order to bring to light a genetic disease for which there is a preventive or corrective treatment

Applications:

  • Oncogenetics (chemotherapy),
  • Cardiology (antihypertenseurs, antiarrhythmics)
  • Psychiatry (anti-depressors)
  • Other (potentially all kind of drugs)

Pharmacogenetics and cancer

Oncology is a good target for pharmacogenetics, as cancer is often caused by both genetic and environment factors.

Pharmacogenetics testing is today applied by many oncologists on chemotherapy treatment against cancer. The results of these kinds of tests can help them decide the best treatment option, as well as dosage recommendations, obtaining better therapeutical results while reducing side effects

Thanks to the information obtained from pharmacogenetic tests, doctors can adjust the chemotherapeutical dosage to the personal needs of each patient.

Pharmacogenetics is the study of how people’s genotype affects their response to drugs.More and more, the prescription of active molecules is done after a molecular profile susceptibility study concerning the drug, in order to adapt the dosage and optimize the efficacy of the treatment, and also limiting the undesirable effects.The main genes implicated are the Cytochrome P450 gene family. Depending on the genetic profile, it is also possible to verify the therapeutic effect or the inefficacity of a molecule:

  • Genetic screening in order to determine the eligibility of patients to certain treatments
  • Genetic screening in order to detect an iatrogenic risk
  • Genetic screening of patients in order to define a better dosage
  • Genetic screening in order to bring to light a genetic disease for which there is a preventive or corrective treatment

Applications:

  • Oncogenetics (chemotherapy),
  • Cardiology (antihypertenseurs, antiarrhythmics)
  • Psychiatry (anti-depressors)
  • Other (potentially all kind of drugs)

Pharmacogenetics and cancer

Oncology is a good target for pharmacogenetics, as cancer is often caused by both genetic and environment factors.

Pharmacogenetics testing is today applied by many oncologists on chemotherapy treatment against cancer. The results of these kinds of tests can help them decide the best treatment option, as well as dosage recommendations, obtaining better therapeutical results while reducing side effects

Thanks to the information obtained from pharmacogenetic tests, doctors can adjust the chemotherapeutical dosage to the personal needs of each patient.